Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.71 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.71 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.71 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.71 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25193481 | 1.00 | TEAD1 (0.71) | TEAD1TEAD4TEAD2TEAD3P2RY14 | |
| SCHEMBL30375620 | 0.92 | TEAD1 (0.72) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL24015683 | 0.92 | TEAD1 (0.72) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL24016563 | 0.92 | TEAD1 (0.72) | TEAD1TEAD4TEAD2TEAD3P2RY14 | |
| SCHEMBL24016194 | 0.91 | TEAD1 (0.71) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL30376339 | 0.91 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3P2RY14 | |
| SCHEMBL30376195 | 0.91 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3P2RY14 | |
| SCHEMBL24015901 | 0.91 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3P2RY14 | |
| SCHEMBL25189431 | 0.91 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3P2RY14 | |
| SCHEMBL24015676 | 0.90 | TEAD1 (0.69) | TEAD1TEAD4TEAD2TEAD3ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426700-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | Merck Patent GmbH (DE) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023078813-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | MERCK PATENT GMBH (DE) | 2023-05-11 | — | — | WO | disclosed |