Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ALDH1A3 | P47895 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19151711 | 0.83 | ALDH1A1 (0.49) | KDM4ERECQLALDH1A3ALDH1A1GAA | |
| SCHEMBL24522285 | 0.82 | KDM4E (0.42) | KDM4ERECQLALDH1A3ALDH1A1GAA | |
| SCHEMBL19152187 | 0.81 | ALDH1A3 (0.49) | ALDH1A3ALDH1A1GAAHPGDMAPK1 | |
| SCHEMBL22523017 | 0.78 | ALDH1A1 (0.46) | KDM4EALDH1A3ALDH1A1GAAHPGD | |
| SCHEMBL7344800 | 0.76 | ALDH1A1 (0.41) | ALDH1A1OPRD1 | |
| SCHEMBL18789903 | 0.73 | KMT2A (0.44) | ALDH1A3ALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL13326993 | 0.73 | MEN1 (0.47) | ALDH1A3ALDH1A1GAAHPGDHTT | |
| SCHEMBL21725472 | 0.71 | ALDH1A1 (0.50) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL10133331 | 0.71 | TRIM24 (0.57) | KDM4EALDH1A1GAASMN1; SMN2HTT | |
| SCHEMBL23375915 | 0.70 | ALDH1A1 (0.41) | RECQLALDH1A1GAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508477-B1 | C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2021-11-10 | — | — | EP | disclosed |