Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 14/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | HTR2C | P28335 | 7/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22957645 | 0.94 | SLC6A4 (0.49) | HTR2ASLC6A4KCNH2HTR2CSLC6A2 | |
| SCHEMBL24224753 | 0.90 | HTR2A (0.54) | HTR2ASLC6A4KCNH2HTR2CHTR2B | |
| SCHEMBL22957894 | 0.85 | RIPK1 (0.48) | HTR2ASLC6A4KCNH2HTR2CHTR2B | |
| SCHEMBL22957811 | 0.84 | HTR2A (0.55) | HTR2ASLC6A4KCNH2HTR2CHTR2B | |
| SCHEMBL22957615 | 0.83 | RIPK1 (0.62) | HTR2ASLC6A4KCNH2HTR2CSLC6A2 | |
| SCHEMBL23052672 | 0.83 | HTR2A (0.49) | HTR2AHTR2CHTR2BRIPK1 | |
| SCHEMBL20472348 | 0.80 | HTR2C (0.56) | HTR2ASLC6A4HTR2CHTR2BSLC6A2 | |
| SCHEMBL29786681 | 0.80 | HTR2C (0.56) | HTR2ASLC6A4HTR2CHTR2BSLC6A2 | |
| SCHEMBL18374001 | 0.79 | HTR2C (0.51) | HTR2ASLC6A4HTR2CHTR2BSLC6A2 | |
| SCHEMBL22393284 | 0.79 | RIPK1 (0.70) | HTR2AHTR2CHTR2BRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3580220-B1 | AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-11-17 | — | — | EP | disclosed |