Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22957811 | 0.94 | HTR2A (0.55) | HTR2ASLC6A4KCNH2HTR2CHTR2B | |
| SCHEMBL24018764 | 0.90 | HTR2A (0.50) | HTR2ASLC6A4KCNH2HTR2CHTR2B | |
| SCHEMBL22957645 | 0.84 | SLC6A4 (0.49) | HTR2ASLC6A4KCNH2HTR2CSLC6A2 | |
| SCHEMBL22957615 | 0.81 | RIPK1 (0.62) | HTR2ASLC6A4KCNH2HTR2CRIPK1 | |
| SCHEMBL22957853 | 0.81 | NPY1R (0.49) | HTR2ASLC6A4KCNH2HTR2CHTR2B | |
| SCHEMBL22470674 | 0.80 | HTR2C (0.58) | HTR2ASLC6A4HTR2CHTR2BRIPK1 | |
| SCHEMBL30175236 | 0.80 | HTR2C (0.58) | HTR2ASLC6A4HTR2CHTR2BRIPK1 | |
| SCHEMBL16872415 | 0.80 | HTR2A (0.54) | HTR2ASLC6A4HTR2CHTR2BRIPK1 | |
| SCHEMBL17111303 | 0.80 | HTR2A (0.54) | HTR2AHTR2CHTR2B | |
| SCHEMBL22470688 | 0.79 | HTR2A (0.50) | HTR2AHTR2CHTR2BRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3943488-A1 | SUBSTITUTED HETEROCYCLIC AMIDE COMPOUND AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2022-01-26 | — | — | EP | disclosed |