Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 4/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 3/20 | 0.35 |
| ▸ | HRH1 | P35367 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24023416 | 0.85 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL24023233 | 0.80 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL24023370 | 0.80 | PIK3CA (0.37) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL24023241 | 0.78 | PIK3CA (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL30476425 | 0.78 | PIK3CG (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL571475 | 0.78 | PIK3CG (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL1939295 | 0.78 | PIK3CG (0.39) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL24023364 | 0.75 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CBPIK3CGGAK | |
| SCHEMBL24023374 | 0.75 | CDC7 (0.39) | ALDH1A1HPGDCDC7DBF4SMN1; SMN2 | |
| SCHEMBL15801542 | 0.73 | PIK3CA (0.51) | PIK3CAPIK3CDPIK3CBPIK3CGGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353607-A1 | PI3K INHIBITORS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2021-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353607-A1 | PI3K INHIBITORS AND USES THEREOF | PIK3CA, AKT3, GSK3B | PIK3CA 1/4885PIK3CD 8/4885PIK3CB 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.