Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24023234 | 0.80 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL24023364 | 0.78 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL3490772 | 0.76 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL3490628 | 0.74 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL24023370 | 0.73 | PIK3CA (0.37) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL1938991 | 0.72 | PIK3CD (0.56) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL571448 | 0.71 | PIK3CG (0.71) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL3490009 | 0.70 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL24023232 | 0.68 | PIK3CA (0.54) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL3782912 | 0.68 | KMT2A (0.46) | PI4KBMEN1HTTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353607-A1 | PI3K INHIBITORS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2021-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353607-A1 | PI3K INHIBITORS AND USES THEREOF | PIK3CA, AKT3, GSK3B | PIK3CA 1/4885PIK3CD 8/4885PIK3CG 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.