Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24023424 | 0.87 | PIK3CA (0.38) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL24023419 | 0.83 | CDC7 (0.40) | ALDH1A1LMNATRPM8CDC7DBF4 | |
| SCHEMBL24023335 | 0.81 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL24023234 | 0.80 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL24023393 | 0.79 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CBPIK3CGPI4KB | |
| SCHEMBL24023377 | 0.79 | CDC7 (0.36) | ALDH1A1LMNACDC7DBF4MAPK14 | |
| SCHEMBL24023330 | 0.77 | OPRM1 (0.36) | PIK3CAPIK3CDPIK3CBPIK3CGCDC7 | |
| SCHEMBL24023248 | 0.76 | MAPK14 (0.37) | ALDH1A1LMNAMAPK14PI4KBIKBKB | |
| SCHEMBL24023233 | 0.73 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL3085308 | 0.69 | PIK3CD (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353607-A1 | PI3K INHIBITORS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2021-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353607-A1 | PI3K INHIBITORS AND USES THEREOF | PIK3CA, AKT3, GSK3B | PIK3CA 1/4885PIK3CD 8/4885PIK3CB 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.