Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 6/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17194922 | 0.80 | TLR8 (0.40) | TYK2HTR2CHTR2AHTR2BP2RX7 | |
| SCHEMBL7869431 | 0.80 | HTR2C (0.39) | HTR2CHTR2AHTR2BCASP6CTDSP1 | |
| SCHEMBL30622218 | 0.78 | KDM4E (0.48) | TYK2HTR2CHTR2AHTR2BP2RX7 | |
| SCHEMBL29132971 | 0.78 | KDM4E (0.48) | TYK2HTR2CHTR2AHTR2BP2RX7 | |
| SCHEMBL20155915 | 0.77 | TYK2 (0.35) | TYK2HTR2CHTR2AHTR2BABL1 | |
| SCHEMBL20155993 | 0.76 | ADRA2A (0.33) | ADRA2AADRA2BADRA2CP2RX7DRD2 | |
| SCHEMBL18415070 | 0.76 | TYK2 (0.37) | TYK2HTR2CHTR2AHTR2BALDH1A1 | |
| SCHEMBL20150102 | 0.76 | TYK2 (0.37) | TYK2HTR2CHTR2AHTR2BALDH1A1 | |
| SCHEMBL20230885 | 0.76 | TYK2 (0.46) | TYK2HTR2CHTR2AHTR2BCASP6 | |
| SCHEMBL17198826 | 0.75 | CCNT1 (0.40) | TYK2CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220508-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2022-01-11 | — | — | US | disclosed |
| US-11174265-B2 | — | — | 2021-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11220508-B2 | TYK2 inhibitors and uses thereof | TYK2, JAK2, JAK1 | TYK2 1/4885HTR2C 3262/4885HTR2A 3475/4885 |
| US-11174265-B2 | — | TYK2, JAK2, JAK1 | TYK2 1/4885HTR2C 2864/4885HTR2A 3149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.