Alpha-Ketoglutaric Acid

Alpha-Ketoglutaric Acid

SCHEMBL2402805

C=C.O=C(O)CCC(=O)C(=O)O

nearest known ligand 0.88

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EGLN1 Q9GZT9 3/20 0.88
▸ OR51E2 Q9H255 2/20 0.88
▸ MAPK1 P28482 1/20 0.88
▸ SLC13A3 Q8WWT9 1/20 0.88
▸ LMNA P02545 6/20 0.56
▸ ALKBH5 Q6P6C2 1/20 0.56
▸ SUCNR1 Q9BXA5 1/20 0.56
▸ SLC15A2 Q16348 1/20 0.43
▸ SLC22A6 Q4U2R8 1/20 0.42
▸ TSHR P16473 2/20 0.40
▸ NFKB1 P19838 1/20 0.40
▸ PMP22 Q01453 1/20 0.40
▸ KDM4E B2RXH2 2/20 0.39
▸ KDM5C P41229 2/20 0.39
▸ PHF8 Q9UPP1 2/20 0.39
▸ KDM2A Q9Y2K7 2/20 0.39
▸ KDM6B O15054 1/20 0.39
▸ FOLH1 Q04609 1/20 0.39
▸ GABRR1 P24046 1/20 0.39
▸ FFAR3 O14843 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alpha-Ketoglutaric Acid SCHEMBL3776640 0.94 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL932116 0.94 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL29783374 0.94 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL7400 0.94 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL17127347 0.94 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL30208560 0.94 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL30029036 0.94 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL3806602 0.90 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL9782859 0.90 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL4896335 0.90 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101918539-A Light driven CO from autotrophs comprising a fermentation gene cassette2Reduction to organic compounds for use as fuels or as industrial semi-finished products UNIV AMSTERDAM 2010-12-15 — — CN claimed
US-11008593-B2 Process for producing 1,3-propanediol compound Photanol, B.V. 2021-05-18 — — US disclosed
US-20190345523-A1 PROCESS OF PRODUCING AN ORGANIC COMPOUND AND AN INTERMEDIARY COMPOUND UNIVERSITEIT VAN AMSTERDAM (NL) 2019-11-14 — — US disclosed
US-20190177752-A1 Process for Producing an Organic Compound PHOTANOL BV. (NL) 2019-06-13 — — US disclosed
US-10131924-B2 Process for producing an organic compound and an intermediary compound PHOTANOL B.V. (NL) 2018-11-20 — — US disclosed
US-20160083756-A1 PROCESS FOR PRODUCING AN ORGANIC COMPOUND RENOLIT HEALTHCARE B.V. (NL) 2016-03-24 — — US disclosed
US-9228210-B2 Process for producing an organic compound PHOTANOL B.V. (NL) 2016-01-05 — — US disclosed
US-20110212498-A1 LIGHT-DRIVEN CO2 REDUCTION TO ORGANIC COMPOUNDS TO SERVE AS FUELS OR AS INDUSTRIAL HALF PRODUCTS BY AN AUTOTROPH CONTAINING A FERMENTATIVE GENE CASSETTE UNIVERSITEIT VAN AMSTERDAM (NL) 2011-09-01 — — US disclosed
CN-101918539-A Light driven CO from autotrophs comprising a fermentation gene cassette2Reduction to organic compounds for use as fuels or as industrial semi-finished products UNIV AMSTERDAM 2010-12-15 — — CN disclosed
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