Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA1 | Q15788 | 1/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
| ▸ | TACR3 | P29371 | 6/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462376 | 1.00 | NCOA1 (0.54) | NCOA1NCOA3TACR3ADORA2AADORA1 | |
| SCHEMBL2402485 | 0.80 | NCOA1 (0.55) | NCOA1NCOA3TACR3IKBKBGRM2 | |
| SCHEMBL4563284 | 0.77 | NCOA1 (0.52) | NCOA1NCOA3TACR3GRM2KDM4E | |
| SCHEMBL30647460 | 0.76 | NCOA1 (0.57) | NCOA1NCOA3TACR3IKBKBGRM2 | |
| SCHEMBL5271308 | 0.75 | NCOA1 (0.55) | NCOA1NCOA3ADORA2AADORA1IKBKB | |
| SCHEMBL5202032 | 0.74 | NCOA1 (0.65) | NCOA1NCOA3IKBKBGRM2KDM4E | |
| SCHEMBL30647468 | 0.73 | NCOA1 (0.43) | NCOA1NCOA3TACR3ADORA2AADORA1 | |
| SCHEMBL30647505 | 0.73 | NCOA1 (0.53) | NCOA1NCOA3TACR3IKBKBGRM2 | |
| SCHEMBL31214767 | 0.72 | NCOA1 (0.59) | NCOA1NCOA3IKBKBGRM2KDM4E | |
| SCHEMBL30604087 | 0.72 | NCOA1 (0.52) | NCOA1NCOA3TACR3GRM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549872-A1 | TRPV4 ANTAGONISTS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119701-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |