Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
| ▸ | TACR3 | P29371 | 10/20 | 0.46 |
| ▸ | TACR2 | P21452 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819716 | 0.84 | NCOA1 (0.47) | NCOA1NCOA3TACR3TACR2KDM4E | |
| SCHEMBL2402485 | 0.83 | NCOA1 (0.55) | NCOA1NCOA3TACR3KDM4ERPS6KB1 | |
| SCHEMBL30604087 | 0.81 | NCOA1 (0.52) | NCOA1NCOA3TACR3KDM4ERPS6KB1 | |
| SCHEMBL30647460 | 0.80 | NCOA1 (0.57) | NCOA1NCOA3TACR3KDM4EGRM2 | |
| SCHEMBL30604071 | 0.80 | KDM4E (0.49) | NCOA1NCOA3TACR3KDM4ERPS6KB1 | |
| SCHEMBL30604085 | 0.78 | KDM4E (0.47) | NCOA1NCOA3TACR3KDM4ELMNA | |
| SCHEMBL30604131 | 0.78 | KDM4E (0.47) | NCOA1NCOA3TACR3KDM4ELMNA | |
| SCHEMBL2462376 | 0.77 | NCOA1 (0.54) | NCOA1NCOA3TACR3KDM4EGRM2 | |
| SCHEMBL2402873 | 0.77 | NCOA1 (0.54) | NCOA1NCOA3TACR3KDM4EGRM2 | |
| SCHEMBL30604108 | 0.77 | NCOA1 (0.48) | NCOA1NCOA3TACR3KDM4ERPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137155-A1 | QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES | AstraZeneca AB (SE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008115140-A1 | QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | WO | disclosed |