SCHEMBL2403537

SCHEMBL2403537

Cc1c(Oc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1CCN(C(C=O)c2cccc(Cl)c2)CC1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.59
CYP2C9 P11712 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2406799 0.92 GPR119 (0.61) GPR119CYP2C9
SCHEMBL2405135 0.91 GPR119 (0.62) GPR119CYP2C9
SCHEMBL2402781 0.90 GPR119 (0.60) GPR119CYP2C9
SCHEMBL2407525 0.89 GPR119 (0.59) GPR119CYP2C9
SCHEMBL5189058 0.88 GPR119 (0.63) GPR119CYP2C9
SCHEMBL1897817 0.88 GPR119 (0.63) GPR119CYP2C9
SCHEMBL2403128 0.87 GPR119 (0.60) GPR119CYP2C9
SCHEMBL3735863 0.86 GPR119 (0.60) GPR119CYP2C9
SCHEMBL5190218 0.85 GPR119 (0.60) GPR119CYP2C9
SCHEMBL2403676 0.85 GPR119 (0.61) GPR119CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4777244-B2 2011-09-21 JP claimed
JP-2007528856-A 2007-10-18 JP claimed
EP-1644357-A1 TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2006-04-12 EP claimed
WO-2005007647-A1 TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2005-01-27 WO claimed