Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.42 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16113553 | 0.79 | HCAR2 (0.52) | MAPK14HCAR2LCKFFAR2NPC1 | |
| SCHEMBL13623803 | 0.78 | HCAR2 (0.45) | MAPK14HCAR2LCKTMPRSS15FFAR2 | |
| SCHEMBL4252915 | 0.77 | HCAR2 (0.46) | MAPK14HCAR2LCKTMPRSS15FFAR2 | |
| SCHEMBL21552094 | 0.77 | TMPRSS15 (0.58) | MAPK14HCAR2LCKTMPRSS15FFAR2 | |
| SCHEMBL9296920 | 0.77 | MAPK14 (0.51) | MAPK14LCKTMPRSS15FFAR2LIMK1 | |
| SCHEMBL13610843 | 0.74 | HCAR2 (0.44) | MAPK14HCAR2LCKTMPRSS15FFAR2 | |
| SCHEMBL4249606 | 0.74 | HCAR2 (0.41) | MAPK14HCAR2LCKFFAR2 | |
| SCHEMBL12715517 | 0.73 | MAPK14 (0.53) | MAPK14LCKTMPRSS15NPC1CYP1A2 | |
| SCHEMBL24348890 | 0.72 | MAPK14 (0.55) | MAPK14LCKTMPRSS15NPC1RAB9A | |
| SCHEMBL4299723 | 0.72 | BCHE (0.43) | MAPK14P2RY2HCAR2LCKCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021231474-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS, INC. (US) | 2021-11-18 | — | — | WO | disclosed |