Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | EEF2K | O00418 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25753551 | 1.00 | CETP (0.32) | CETPEEF2KNOTUMTACR1ALDH1A1 | |
| SCHEMBL25622767 | 0.93 | TACR1 (0.34) | CETPEEF2KNOTUMTACR1ALDH1A1 | |
| SCHEMBL25753566 | 0.93 | TACR1 (0.34) | CETPEEF2KNOTUMTACR1ALDH1A1 | |
| SCHEMBL24036736 | 0.93 | TACR1 (0.34) | CETPEEF2KNOTUMTACR1ALDH1A1 | |
| SCHEMBL24036737 | 0.89 | CXCR2 (0.36) | EEF2KNOTUMTACR1ALDH1A1 | |
| SCHEMBL24036739 | 0.89 | CXCR2 (0.36) | CETPEEF2KALDH1A1 | |
| SCHEMBL25753562 | 0.89 | CXCR2 (0.36) | CETPEEF2KALDH1A1 | |
| SCHEMBL25753553 | 0.89 | CXCR2 (0.36) | EEF2KNOTUMTACR1ALDH1A1 | |
| SCHEMBL30388831 | 0.88 | SLC13A3 (0.35) | CETPEEF2K | |
| SCHEMBL25622766 | 0.88 | RXRA (0.37) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | UBE CORPORATION (JP) | 2023-06-22 | — | — | US | disclosed |
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | UBE CORPORATION (JP) | 2023-06-22 | — | — | US | disclosed |
| WO-2021230325-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | 宇部興産株式会社 | 2021-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | DHFR, DPYD, CYP2D6 | CETP 4134/4885EEF2K 1397/4885NOTUM 4230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.