Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.41 |
| ▸ | RET | P07949 | 10/20 | 0.41 |
| ▸ | KIF5B | P33176 | 10/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 3/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | IGFBP5 | P24593 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011251 | 0.88 | IRAK4 (0.39) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL18013039 | 0.83 | EGFR (0.42) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL3320604 | 0.81 | RET (0.31) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL25552038 | 0.81 | EGFR (0.40) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL13195987 | 0.81 | MAP4K4 (0.41) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL15971471 | 0.81 | IRAK4 (0.40) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL30562969 | 0.78 | KMO (0.35) | KDRRETKIF5BEGFRRAF1 | |
| SCHEMBL21664330 | 0.78 | KMO (0.35) | KDRRETKIF5BEGFRRAF1 | |
| SCHEMBL21456827 | 0.77 | EGFR (0.37) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL22323303 | 0.77 | TRPA1 (0.50) | KDRRETKIF5BEGFRRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021231400-A1 | BIS-ARYL ETHERS CONTAINING N-ACYL AZETIDINE AS EGFR/HER2 INHIBITORS | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2021-11-18 | — | — | WO | disclosed |
| WO-2021231400-A1 | BIS-ARYL ETHERS CONTAINING N-ACYL AZETIDINE AS EGFR/HER2 INHIBITORS | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2021-11-18 | — | — | WO | disclosed |