Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.49 |
| ▸ | BHMT | Q93088 | 5/20 | 0.49 |
| ▸ | GSR | P00390 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | GRM8 | O00222 | 1/20 | 0.48 |
| ▸ | GRM6 | O15303 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.48 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL2404172 | 1.00 | OTC (0.49) | OTCBHMTGSRCYP1A2GRM8 | |
| Azelaic Acid SCHEMBL14334673 | 0.98 | BHMT (0.50) | OTCBHMTGSRCYP1A2GRM8 | |
| Azelaic Acid SCHEMBL14333631 | 0.98 | BHMT (0.50) | OTCBHMTGSRCYP1A2GRM8 | |
| Arginine SCHEMBL7650337 | 0.97 | OTC (0.49) | OTCBHMTGSRCYP1A2GRM8 | |
| Arginine SCHEMBL7650333 | 0.97 | OTC (0.49) | OTCBHMTGSRCYP1A2GRM8 | |
| Arginine SCHEMBL1279618 | 0.95 | GSR (0.50) | OTCBHMTGSRCYP1A2GRM8 | |
| Arginine SCHEMBL1279619 | 0.95 | GSR (0.50) | OTCBHMTGSRCYP1A2GRM8 | |
| Arginine SCHEMBL573880 | 0.94 | GSR (0.58) | OTCBHMTGSRCYP1A2GRM8 | |
| Arginine SCHEMBL6803653 | 0.94 | GSR (0.58) | OTCBHMTGSRCYP1A2GRM8 | |
| Arginine SCHEMBL4749671 | 0.94 | GSR (0.58) | OTCBHMTGSRCYP1A2GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2369925-A1 | AN L-ARGININE-BASED FORMULATION FOR ORAL ABSORPTION | Geshuri, Benzion (IL) | 2011-10-05 | — | — | EP | disclosed |
| US-20110236508-A1 | L-ARGININE-BASED FORMULATION FOR ORAL ABSORPTION | GESHURI BENZION | 2011-09-29 | — | — | US | disclosed |
| WO-2010061395-A1 | AN L-ARGININE-BASED FORMULATION FOR ORAL ABSORPTION | GESHURI BENZION (IL) | 2010-06-03 | — | — | WO | disclosed |