Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.82 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.82 |
| ▸ | HCK | P08631 | 14/20 | 0.82 |
| ▸ | TNF | P01375 | 1/20 | 0.70 |
| ▸ | SRC | P12931 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2405918 | 0.91 | MAPK14 (0.75) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL2408004 | 0.90 | MAPK14 (1.00) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL31086867 | 0.90 | MAPK14 (0.86) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL2405604 | 0.90 | MAPK14 (0.86) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL2405358 | 0.88 | MAPK14 (0.74) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL12540478 | 0.87 | HCK (0.83) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL2534207 | 0.87 | MAPK14 (0.75) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL13563524 | 0.87 | MAPK14 (0.78) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL2533684 | 0.87 | MAPK14 (0.78) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL2532803 | 0.86 | MAPK14 (0.76) | MAPK14MAPK12HCKTNFSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509595-B1 | INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION | RESPIVERT LTD (GB) | 2018-04-11 | — | — | EP | disclosed |
| US-20180000830-A1 | INHIBITORS OF HEMOPOIETIC CELL KINASE (P-59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION | RESPIVERT LIMITED (GB) | 2018-01-04 | — | — | US | disclosed |
| EP-2370428-B1 | P38 MAP KINASE INHIBITORS | RESPIVERT LTD (GB) | 2016-08-10 | — | — | EP | disclosed |
| US-8975285-B2 | P38 MAP kinase inhibitors | RESPIVERT LTD. (GB) | 2015-03-10 | — | — | US | disclosed |
| US-8975285-B2 | P38 MAP kinase inhibitors | RESPIVERT LTD. (GB) | 2015-03-10 | — | — | US | disclosed |
| US-20140114064-A1 | P38 MAP KINASE INHIBITORS | RESPIVERT LTD. (GB) | 2014-04-24 | — | — | US | disclosed |
| US-8618140-B2 | P38 MAP kinase inhibitors | RESPIVERT LTD (GB) | 2013-12-31 | — | — | US | disclosed |
| US-20130012512-A1 | P38 MAP kinase inhibitors | ITO KAZUHIRO (GB) | 2013-01-10 | — | — | US | disclosed |
| US-20130012512-A1 | P38 MAP kinase inhibitors | ITO KAZUHIRO (GB) | 2013-01-10 | — | — | US | disclosed |
| US-8299073-B2 | P38 MAP kinase inhibitors | RESPIVERT LTD. (GB) | 2012-10-30 | — | — | US | disclosed |
| US-8293748-B2 | p38 MAP kinase inhibitors | RESPIVERT LTD. (GB) | 2012-10-23 | — | — | US | disclosed |
| US-8293748-B2 | p38 MAP kinase inhibitors | RESPIVERT LTD. (GB) | 2012-10-23 | — | — | US | disclosed |
| US-20120244120-A1 | INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION | RESPIVERT LTD. (GB) | 2012-09-27 | — | — | US | disclosed |
| US-20110294812-A1 | P38 MAP KINASE INHIBITORS | RESPIVERT LTD. (GB) | 2011-12-01 | — | — | US | disclosed |
| EP-2370428-A1 | P38 MAP KINASE INHIBITORS | Respivert Limited (GB) | 2011-10-05 | — | — | EP | disclosed |
| US-20110212962-A1 | P38 MAP KINASE INHIBITORS | RESPIVERT LTD. (GB) | 2011-09-01 | — | — | US | disclosed |
| US-20110212962-A1 | P38 MAP KINASE INHIBITORS | RESPIVERT LTD. (GB) | 2011-09-01 | — | — | US | disclosed |
| WO-2010067131-A1 | P38 MAP KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180000830-A1 | INHIBITORS OF HEMOPOIETIC CELL KINASE (P-59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION | HCK, CDK9, PHKG1 | MAPK14 257/4885MAPK12 621/4885HCK 1/4885 |
| US-20120244120-A1 | INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION | HCK, CDK9, TTK | MAPK14 418/4885MAPK12 634/4885HCK 1/4885 |
| US-20110294812-A1 | P38 MAP KINASE INHIBITORS | MAPK1, MAP3K1, MAPK3 | MAPK14 10/4885MAPK12 13/4885HCK 348/4885 |
| US-20130012512-A1 | P38 MAP kinase inhibitors | MAPK1, MAPK3, MAPK6 | MAPK14 33/4885MAPK12 31/4885HCK 2830/4885 |
| US-20110212962-A1 | P38 MAP KINASE INHIBITORS | MAPK1, MAPK3, MAPK6 | MAPK14 33/4885MAPK12 31/4885HCK 2830/4885 |
| US-20140114064-A1 | P38 MAP KINASE INHIBITORS | MAPK1, MAPK3, MAPK6 | MAPK14 33/4885MAPK12 31/4885HCK 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.