Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | DHODH | Q02127 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ACP1 | P24666 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.52 |
| ▸ | C1R | P00736 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2404532 | 0.89 | ACP1 (0.57) | MEN1KMT2ADHODHKDM4ESMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2402407 | 0.86 | ACP1 (0.54) | MEN1KMT2ADHODHKDM4ESMN1; SMN2 | |
| SCHEMBL8324531 | 0.82 | MEN1 (0.77) | MEN1KMT2ADHODHKDM4ESMN1; SMN2 | |
| SCHEMBL8620618 | 0.82 | ACP1 (0.50) | MEN1KMT2ADHODHKDM4ESMN1; SMN2 | |
| SCHEMBL31620661 | 0.81 | MEN1 (0.71) | MEN1KMT2ADHODHKDM4ESMN1; SMN2 | |
| SCHEMBL1898944 | 0.81 | MEN1 (0.71) | MEN1KMT2ADHODHKDM4ESMN1; SMN2 | |
| SCHEMBL18746 | 0.80 | KDM4E (0.83) | MEN1KMT2ADHODHKDM4ESMN1; SMN2 | |
| SCHEMBL29359819 | 0.80 | KDM4E (0.83) | MEN1KMT2ADHODHKDM4ESMN1; SMN2 | |
| SCHEMBL19520848 | 0.80 | MEN1 (0.73) | MEN1KMT2ADHODHKDM4ESMN1; SMN2 | |
| SCHEMBL10390275 | 0.79 | ACP1 (0.56) | MEN1KMT2ADHODHKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549872-A1 | TRPV4 ANTAGONISTS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119701-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |