Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 11/20 | 0.63 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PTGFR | P43088 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2404536 | 0.88 | DHODH (0.52) | DHODHPDE10ALMNATSHRCYP2D6 | |
| Trifluoroacetic Acid SCHEMBL2402411 | 0.85 | DHODH (0.49) | DHODHPDE10ALMNATSHRCYP2D6 | |
| SCHEMBL29290337 | 0.80 | DHODH (0.69) | DHODHPDE10ALMNATSHRCYP2D6 | |
| SCHEMBL2429278 | 0.79 | PDE10A (0.45) | DHODHPDE10ALMNATSHRCYP2D6 | |
| SCHEMBL28048083 | 0.78 | LMNA (0.49) | DHODHPDE10ALMNATSHRCYP2C19 | |
| SCHEMBL24122754 | 0.78 | LMNA (1.00) | DHODHPDE10ALMNATSHRCYP2D6 | |
| SCHEMBL3908668 | 0.78 | DHODH (0.71) | DHODHPDE10ALMNATSHRCYP2D6 | |
| Oxycinchophen SCHEMBL1170683 | 0.78 | DHODH (1.00) | DHODHPDE10ALMNATSHRCYP2D6 | |
| Oxycinchophen SCHEMBL29460357 | 0.78 | DHODH (1.00) | DHODHPDE10ALMNATSHRCYP2D6 | |
| Oxycinchophen SCHEMBL31654029 | 0.78 | DHODH (1.00) | DHODHPDE10ALMNATSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549872-A1 | TRPV4 ANTAGONISTS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119701-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |