Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30219772 | 1.00 | TSHR (0.40) | TSHRMAPK1DAOMRGPRX4KCNH2 | |
| SCHEMBL25698437 | 0.85 | DAO (0.37) | DAOKCNH2TMEM97ADRB2PDE2A | |
| SCHEMBL25695740 | 0.84 | CYP3A4 (0.41) | TSHRMAPK1HTR1ATAAR1CYP19A1 | |
| SCHEMBL24046676 | 0.83 | TSHR (0.54) | TSHRMAPK1KCNH2HTR1ACNR1 | |
| SCHEMBL30219792 | 0.83 | TSHR (0.54) | TSHRMAPK1KCNH2HTR1ACNR1 | |
| SCHEMBL30219766 | 0.77 | CYP1A2 (0.46) | DAOMRGPRX4ROCK1CYP19A1MEN1 | |
| SCHEMBL24046370 | 0.77 | CYP1A2 (0.46) | DAOMRGPRX4ROCK1CYP19A1MEN1 | |
| SCHEMBL24046372 | 0.74 | ADRB2 (0.38) | DAOKCNH2TMEM97ADRB2CYP3A4 | |
| SCHEMBL30219759 | 0.74 | ADRB2 (0.38) | DAOKCNH2TMEM97ADRB2CYP3A4 | |
| SCHEMBL30219774 | 0.73 | TSHR (0.41) | TSHRMAPK1MRGPRX4MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021236885-A1 | PIPERIDINE-2,6-DIONES AS SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-11-25 | — | — | WO | disclosed |