Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24046676 | 1.00 | TSHR (0.54) | TSHRMAPK1TAAR1HTR2AHTR2B | |
| SCHEMBL24046632 | 0.83 | TSHR (0.40) | TSHRMAPK1TAAR1HTR1AROCK1 | |
| SCHEMBL30219772 | 0.83 | TSHR (0.40) | TSHRMAPK1TAAR1HTR1AROCK1 | |
| SCHEMBL15432467 | 0.81 | TAAR1 (0.57) | TSHRTAAR1HTR2AHTR2BHTR2C | |
| Ammonia Solution, Strong SCHEMBL28048257 | 0.80 | TAAR1 (0.56) | TSHRTAAR1HTR2AHTR2BHTR2C | |
| SCHEMBL5176951 | 0.79 | TAAR1 (0.43) | TSHRTAAR1HTR2AHTR2BHTR2C | |
| SCHEMBL25695740 | 0.78 | CYP3A4 (0.41) | TSHRMAPK1TAAR1HTR1AMAOB | |
| SCHEMBL9799352 | 0.76 | TAAR1 (0.64) | TSHRMAPK1TAAR1HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL27770501 | 0.76 | TAAR1 (0.62) | TSHRTAAR1HTR2AHTR2BHTR2C | |
| SCHEMBL8084194 | 0.75 | SIGMAR1 (0.59) | TSHRTAAR1HTR2AHTR2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4153175-A1 | PIPERIDINE-2,6-DIONES AS SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | Dana-Farber Cancer Institute, Inc. (US) | 2023-03-29 | — | — | EP | disclosed |