Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | TP53 | P04637 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | TNKS | O95271 | 3/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24046794 | 0.84 | MAOB (0.63) | MAOBABCB1CYP3A4KDM4EALDH1A1 | |
| SCHEMBL24046795 | 0.84 | TNKS (0.61) | MAOBABCB1CYP3A4KDM4EALDH1A1 | |
| SCHEMBL24046783 | 0.82 | MAOB (0.55) | MAOBABCB1CYP3A4KDM4EALDH1A1 | |
| SCHEMBL24046925 | 0.81 | MAOB (0.64) | MAOBABCB1CYP3A4KDM4EALDH1A1 | |
| SCHEMBL24046788 | 0.79 | MAOB (0.51) | MAOBABCB1CYP3A4KDM4EALDH1A1 | |
| SCHEMBL24046921 | 0.77 | MAOB (0.77) | MAOBABCB1CYP3A4KDM4EALDH1A1 | |
| 4,7-Dimethoxyflavone SCHEMBL3470601 | 0.74 | MAOB (1.00) | MAOBABCB1CYP3A4KDM4EALDH1A1 | |
| SCHEMBL24046782 | 0.72 | CSNK2A2 (0.71) | MAOBABCB1CYP3A4KDM4EALDH1A1 | |
| 7,3',4'-Trimethoxyflavone SCHEMBL987112 | 0.71 | ABCB1 (1.00) | MAOBABCB1CYP3A4KDM4EALDH1A1 | |
| 7,3'-Dimethoxyflavone SCHEMBL718068 | 0.71 | KDM4E (1.00) | MAOBABCB1CYP3A4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021236578-A1 | CHROMEN-4-ONE DERIVATIVES, SUCH AS E.G. FLAVONES, FOR USE AS CK2 INHIBITORS FOR THE TREATMENT OF NEUROINFLAMMATION | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2021-11-25 | — | — | WO | disclosed |