Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.47 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.44 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15855110 | 1.00 | PAOX (0.57) | PAOXSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL18827286 | 1.00 | PAOX (0.57) | PAOXSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL15602662 | 0.98 | SMN1; SMN2 (0.56) | PAOXSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL16293353 | 0.92 | TP53 (0.58) | PAOXSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL18199495 | 0.88 | SMN1; SMN2 (0.66) | SMN1; SMN2TP53ALDH1A1KMT2AHPGD | |
| SCHEMBL22203824 | 0.87 | SMN1; SMN2 (0.50) | PAOXSMN1; SMN2TP53ALDH1A1KMT2A | |
| Trifluoroacetic Acid SCHEMBL21642269 | 0.87 | ALDH1A1 (0.49) | PAOXSMN1; SMN2TP53ALDH1A1KMT2A | |
| Bromide SCHEMBL5240710 | 0.86 | SLC6A5 (0.50) | PAOXSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL22171094 | 0.85 | TP53 (0.51) | PAOXSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL22171105 | 0.85 | TP53 (0.51) | PAOXSMN1; SMN2TP53ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021236775-A1 | SMALL MOLECULE DEGRADERS OF SHP2 PROTEIN | THE REGENTS OF THE UNIVERSITY OFMICHIGAN (US) | 2021-11-25 | — | — | WO | disclosed |