Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 5/20 | 0.53 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.53 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10198728 | 0.86 | — | — | |
| SCHEMBL12846703 | 0.82 | KDM4E (0.49) | KDM4EALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10133641 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL20233843 | 0.80 | GNAI3 (0.49) | GNAI3GNAO1GNAI1KCNH2SOS1 | |
| SCHEMBL10058121 | 0.80 | KCNH2 (0.56) | GNAI3GNAO1GNAI1KCNH2SOS1 | |
| SCHEMBL1956284 | 0.80 | GNAI3 (0.52) | GNAI3GNAO1GNAI1KCNH2SOS1 | |
| SCHEMBL16281580 | 0.80 | KDM4E (0.51) | KDM4EALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL20757923 | 0.79 | KCNH2 (0.46) | GNAI3GNAO1GNAI1KCNH2KDM4E | |
| SCHEMBL2668499 | 0.78 | ALDH1A1 (0.41) | GNAI3GNAO1GNAI1KDM4EALDH1A1 | |
| SCHEMBL1197783 | 0.77 | GNAI3 (0.68) | GNAI3GNAO1GNAI1KCNH2SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3915991-A1 | PYRROLOPYRIMIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE COMPRISING SAME AS ACTIVE INGREDIENT | Voronoi Co., Ltd. (KR) | 2021-12-01 | — | — | EP | disclosed |