Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18981747 | 0.88 | L3MBTL1 (0.49) | SMN1; SMN2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL20449219 | 0.83 | L3MBTL1 (0.49) | SMN1; SMN2ALDH1A1LMNAHPGDMEN1 | |
| SCHEMBL10741387 | 0.75 | L3MBTL1 (0.47) | MAPTSMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL28376763 | 0.74 | L3MBTL1 (0.52) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL25612415 | 0.70 | L3MBTL1 (0.50) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL15129555 | 0.70 | L3MBTL1 (0.42) | SMN1; SMN2ALDH1A1HPGDKMT2ANPC1 | |
| SCHEMBL1110997 | 0.69 | GAA (0.57) | MAPTSMN1; SMN2LMNAHPGDNPC1 | |
| SCHEMBL25612345 | 0.69 | L3MBTL1 (0.49) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL25612343 | 0.69 | L3MBTL1 (0.49) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL28557250 | 0.69 | PTPRG (0.57) | MAPTALDH1A1KMT2AL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390382-B1 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | ARDELYX INC (US) | 2021-12-01 | — | — | EP | disclosed |