Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.43 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24061516 | 0.86 | BTK (0.57) | BTK | |
| SCHEMBL24061553 | 0.85 | BTK (0.57) | BTK | |
| SCHEMBL17646049 | 0.84 | AURKA (0.46) | BTKAURKAAURKBINCENPTPX2 | |
| SCHEMBL24061690 | 0.84 | BTK (0.51) | BTK | |
| SCHEMBL24061646 | 0.80 | BTK (0.47) | BTKAURKAAURKBINCENPTPX2 | |
| SCHEMBL17646034 | 0.79 | BTK (0.61) | BTK | |
| SCHEMBL17645858 | 0.76 | BTK (0.43) | BTKAURKAAURKBINCENPTPX2 | |
| SCHEMBL17645975 | 0.76 | BTK (0.79) | BTK | |
| SCHEMBL21791346 | 0.76 | BTK (0.43) | BTKAURKAAURKBINCENPTPX2 | |
| SCHEMBL17645748 | 0.76 | BTK (0.53) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204382-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-12-01 | — | — | EP | disclosed |