Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118804 | 1.00 | PTGS1 (0.53) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL8561039 | 1.00 | PTGS1 (0.53) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL8089542 | 0.86 | PTGS1 (0.53) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL8127157 | 0.86 | PTGS1 (0.53) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL1131597 | 0.82 | PTGS1 (0.56) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL9336469 | 0.81 | PTGS1 (0.59) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL7780878 | 0.80 | PTGS1 (0.57) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL2579982 | 0.80 | PTGS1 (0.57) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL5174938 | 0.79 | PTGS1 (0.54) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL2865480 | 0.79 | ADRB2 (0.41) | PTGS1LMNAESR1NFKB1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117362165-A | Preparation method of ibuprofen | 山东新华制药股份有限公司 | 2024-01-09 | — | — | CN | claimed |
| CN-113136593-A | Method for synthesizing ibuprofen | 赤峰学院 | 2021-07-20 | — | — | CN | claimed |
| US-6555704-B1 | Preparation of alpha-aryl-propionic acids such as ibuprofen by carbonylating the corresponding 1-arylethyl halide in an acidic aqueous medium containing a phosphine/palladium catalyst; catalyst selectivity; efficiency | BASF CORPORATION | 2003-04-29 | — | — | US | claimed |
| EP-0434343-B2 | Process for preparing ibuprofen and its alkyl esters | ALBEMARLE CORP (US) | 2001-09-26 | — | — | EP | claimed |
| US-6268526-B1 | MIXTURE FORMED FROM AN AROMATIC SUBSTITUTED ALCOHOL AND/OR AN AROMATIC SUBSTITUTED ALKYL HALIDE, AND A COPPER-FREE PALLADIUM CATALYST IS CARBONYLATED WITH CARBON MONOXIDE TO PRODUCE ALPHA-SUBSTITUTED CARBOXYLIC ACID OR ESTER | ALBEMARLE CORPORATION | 2001-07-31 | — | — | US | claimed |
| EP-0535682-B1 | Preparation of aryl-substituted olefins | ALBEMARLE CORP (US) | 1995-07-12 | — | — | EP | claimed |
| EP-0338852-B1 | Process for the carbonylation of arylalkyl halides | HOECHST CELANESE CORP (US) | 1994-11-30 | — | — | EP | claimed |
| US-5322959-A | Producing ibuprofen esters | ETHYL CORPORATION (US) | 1994-06-21 | — | — | US | claimed |
| US-5315027-A | Carbonylation | ETHYL CORPORATION (US) | 1994-05-24 | — | — | US | claimed |
| US-5315029-A | Process for preparing aryl-substituted aliphatic carboxylic acid esters by carbonylation | ETHYL CORPORATION (US) | 1994-05-24 | — | — | US | claimed |
| EP-0356236-B1 | CHLOROETHYLATION OF AROMATIC HYDROCARBONS | ETHYL CORPORATION (US) | 1993-03-31 | — | — | EP | claimed |
| US-5055611-A | Treating with oxygen and solution of monodentate phosphine ligand | ETHYL CORPORATION (US) | 1991-10-08 | — | — | US | claimed |
| EP-0434343-A1 | Process for preparing ibuprofen and its alkyl esters | ALBEMARLE CORPORATION (US) | 1991-06-26 | — | — | EP | claimed |
| US-5001288-A | Haloethylation of aromatic hydrocarbons | ETHYL CORPORATION (US) | 1991-03-19 | — | — | US | claimed |
| US-4990658-A | Process for preparing ibuprofen and its alkyl esters | ETHYL CORPORATION (US) | 1991-02-05 | — | — | US | claimed |
| EP-0356236-A2 | Chloroethylation of aromatic hydrocarbons | ETHYL CORPORATION (US) | 1990-02-28 | — | — | EP | claimed |
| EP-0338852-A1 | Process for the carbonylation of arylalkyl halides | HOECHST CELANESE CORPORATION (US) | 1989-10-25 | — | — | EP | claimed |
| US-4536595-A | Process for the preparation of alpha-aryl-propionic acids and alkaline salts thereof | MONTEDISON S.P.A. (IT) | 1985-08-20 | — | — | US | claimed |
| EP-0076722-B1 | PROCESS FOR THE PREPARATION OF ALPHA-ARYL-PROPIONIC ACIDS AND THEIR ALKALINE SALTS | Montedison S.p.A. (IT) | 1985-02-20 | — | — | EP | claimed |
| EP-0076722-A1 | Process for the preparation of alpha-aryl-propionic acids and their alkaline salts | Montedison S.p.A. (IT) | 1983-04-13 | — | — | EP | claimed |