Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.60 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.60 |
| ▸ | CDK1 | P06493 | 2/20 | 0.60 |
| ▸ | PRKACA | P17612 | 2/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.60 |
| ▸ | CDK2 | P24941 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | GSK3A | P49840 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | PRKX | P51817 | 2/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.60 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.60 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.60 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.60 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2409529 | 1.00 | ALDH1A1 (0.61) | ALDH1A1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL2412896 | 1.00 | ALDH1A1 (0.61) | ALDH1A1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL2413088 | 0.88 | ROCK2 (0.68) | ALDH1A1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL6918948 | 0.87 | HDAC1 (0.73) | ALDH1A1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL12279819 | 0.86 | ALDH1A1 (0.57) | ALDH1A1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL12280060 | 0.84 | NR1H4 (0.59) | ALDH1A1ROCK2ROCK1MAPK1MEN1 | |
| SCHEMBL2407090 | 0.83 | CA1 (0.59) | ALDH1A1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL2408586 | 0.83 | CA1 (0.59) | ALDH1A1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL2409579 | 0.83 | NPSR1 (0.56) | ALDH1A1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL2407415 | 0.83 | SMN1; SMN2 (0.77) | ALDH1A1ROCK2ROCK1PRKG1RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382197-B2 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382197-B2 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20140275093-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275093-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20110212969-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | US | disclosed |
| US-20110212969-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | US | disclosed |
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275093-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC10, HDAC1 | ALDH1A1 1696/4885ROCK2 360/4885ROCK1 210/4885 |
| US-20110212969-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC10, HDAC1 | ALDH1A1 1696/4885ROCK2 360/4885ROCK1 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.