Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 5/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2571507 | 0.81 | HTR2C (0.45) | HTR2BHTR6HTR2CHTR2A | |
| SCHEMBL968179 | 0.77 | HTR2C (0.42) | HTR2BHTR6HTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL967326 | 0.76 | HTR2C (0.41) | HTR2BHTR6HTR2CHTR2A | |
| SCHEMBL8566538 | 0.74 | — | — | |
| SCHEMBL970312 | 0.71 | NOTUM (0.34) | TSHRNPC1 | |
| Trifluoroacetic Acid SCHEMBL967950 | 0.67 | HTR2C (0.37) | HTR2BHTR6HTR2CHTR2A | |
| SCHEMBL10779456 | 0.63 | RAB9A (0.39) | HTR2BHTR6MAPK9TSHRNPC1 | |
| SCHEMBL1290194 | 0.63 | PDE10A (0.42) | DYRK1A | |
| SCHEMBL14572413 | 0.63 | NPC1 (0.41) | TSHRMAPK10NPC1 | |
| SCHEMBL22996563 | 0.62 | TSHR (0.34) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1832590-B1 | Heterotricyclic compounds as CRF receptor antagonists | ONO PHARMACEUTICAL CO (JP) | 2011-09-28 | — | — | EP | claimed |
| US-7034153-B2 | Tricyclic and heterocyclic derivative compounds and drugs containing these compounds as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-04-25 | — | — | US | disclosed |