SCHEMBL24068855

SCHEMBL24068855

COc1ccc(Oc2ccc(C=O)c(OC)c2)cc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.79
CYP1A2 P05177 9/20 0.62
CYP2C19 P33261 3/20 0.62
CYP2C9 P11712 2/20 0.62
LMNA P02545 1/20 0.62
CYP1A1 P04798 7/20 0.56
CYP1B1 Q16678 7/20 0.56
NFE2L2 Q16236 2/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
TRIM24 O15164 1/20 0.51
TYR P14679 1/20 0.51
TRIM33 Q9UPN9 1/20 0.51
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
ERN1 O75460 2/20 0.50
MAPT P10636 2/20 0.50
KDM4E B2RXH2 2/20 0.50
TSHR P16473 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
TNFRSF1A P19438 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28451899 0.90 ALDH1A1 (0.69) ALDH1A1CYP1A2CYP2C19CYP2C9LMNA
SCHEMBL96291 0.89 ALDH1A1 (1.00) ALDH1A1CYP1A2CYP2C19CYP2C9CYP1A1
SCHEMBL28360529 0.88 ALDH1A1 (0.67) ALDH1A1CYP1A2CYP2C19CYP2C9LMNA
Hydrochloric Acid SCHEMBL9456784 0.87 ALDH1A1 (0.96) ALDH1A1CYP1A2CYP2C19CYP2C9CYP1A1
Ethylene SCHEMBL4914414 0.85 ALDH1A1 (0.92) ALDH1A1CYP1A2CYP2C19CYP2C9CYP1A1
Formaldehyde SCHEMBL28854145 0.85 ALDH1A1 (0.92) ALDH1A1CYP1A2CYP2C19CYP2C9CYP1A1
SCHEMBL21660344 0.83 ALDH1A1 (0.59) ALDH1A1CYP1A2CYP2C19CYP2C9LMNA
SCHEMBL756641 0.81 ALDH1A1 (0.51) ALDH1A1CYP1A2CYP2C19CYP2C9LMNA
SCHEMBL24068857 0.81 TYR (0.80) ALDH1A1CYP1A2CYP2C19CYP2C9LMNA
SCHEMBL3181478 0.80 ALDH1A1 (0.76) ALDH1A1CYP1A2CYP2C19CYP2C9LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021238587-A1 MICROMOLECULAR OXATHIAZINE DERIVATIVE AND USE THEREOF 四川大学华西医院 2021-12-02 WO disclosed
CN-111559990-B Micromolecular oxathiazine derivative and application thereof 四川大学华西医院 2021-03-09 CN disclosed
CN-111559990-A Micromolecular oxathiazine derivative and application thereof 四川大学华西医院 2020-08-21 CN disclosed