SCHEMBL24070382

SCHEMBL24070382

CCC[C@@H](OCCN(C)C)C(C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.35
CYP2D6 P10635 3/20 0.35
CHRM2 P08172 3/20 0.35
ADRA2A P08913 3/20 0.35
CHRM1 P11229 3/20 0.35
SLC6A2 P23975 3/20 0.35
SLC6A4 P31645 3/20 0.35
OPRM1 P35372 3/20 0.35
DRD3 P35462 3/20 0.35
SLC6A3 Q01959 3/20 0.35
CHRM4 P08173 2/20 0.35
CHRM5 P08912 2/20 0.35
ADRA2B P18089 2/20 0.35
CHRM3 P20309 2/20 0.35
HRH2 P25021 2/20 0.35
HTR2A P28223 2/20 0.35
HTR2C P28335 2/20 0.35
ADRA1A P35348 2/20 0.35
HRH1 P35367 2/20 0.35
HTR2B P41595 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24070375 1.00 LMNA (0.35) LMNACYP2D6CHRM2ADRA2ACHRM1
SCHEMBL7557809 0.74 CHRM2 (0.39) LMNACYP2D6CHRM2ADRA2ACHRM1
SCHEMBL24171153 0.74 CHRM2 (0.39) LMNACYP2D6CHRM2ADRA2ACHRM1
SCHEMBL24070387 0.73 CHRM2 (0.36) LMNACYP2D6CHRM2ADRA2ACHRM1
SCHEMBL18467471 0.73 THRB (0.36) LMNA
SCHEMBL255537 0.72 CHRM2 (0.38) LMNACYP2D6CHRM2ADRA2ACHRM1
SCHEMBL22021977 0.72 CHRM2 (0.38) LMNACYP2D6CHRM2ADRA2ACHRM1
SCHEMBL14752959 0.70 CHRM2 (0.39) LMNACYP2D6CHRM2ADRA2ACHRM1
SCHEMBL21018055 0.68 CHRM2 (0.38) LMNACYP2D6CHRM2ADRA2ACHRM1
SCHEMBL14748854 0.68 CHRM2 (0.38) LMNACYP2D6CHRM2ADRA2ACHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021239058-A1 FUSED TRICYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF 劲方医药科技(上海)有限公司 2021-12-02 WO disclosed