Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2405515 | 0.92 | CYP1A2 (0.41) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL2406205 | 0.86 | HCRTR2 (0.41) | GAAALDH1A1HCRTR2HCRTR1KMT2A | |
| SCHEMBL2405435 | 0.84 | HTR6 (0.42) | HCRTR2HCRTR1MTNR1AMTNR1BCDK4 | |
| SCHEMBL2406798 | 0.81 | HTR2A (0.44) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL2407555 | 0.80 | CYP1A2 (0.43) | GAACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2410323 | 0.80 | TDO2 (0.39) | HCRTR2HCRTR1MTNR1AMTNR1BCDK4 | |
| SCHEMBL2404557 | 0.80 | CYP1A2 (0.42) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL2408416 | 0.79 | HCRTR2 (0.45) | HCRTR2HCRTR1KMT2AMEN1MTNR1A | |
| SCHEMBL2405442 | 0.79 | TDO2 (0.42) | HCRTR2HTR1AHTR2ASLC6A4 | |
| SCHEMBL2404963 | 0.79 | HCRTR2 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | HCRTR2, HCRTR1, HRH3 | GAA 2389/4885CYP1A2 1070/4885CYP3A4 1054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.