Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16590521 | 0.83 | SLC6A2 (0.38) | SMN1; SMN2TRPM8SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24072577 | 0.80 | TRPM8 (0.38) | SMN1; SMN2TRPM8SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23966775 | 0.78 | KDM4E (0.33) | MAPTALDH1A1KDM4E | |
| SCHEMBL25912590 | 0.77 | SMN1; SMN2 (0.33) | SMN1; SMN2MAPTALDH1A1HTTNPC1 | |
| SCHEMBL23966743 | 0.76 | MEN1 (0.42) | SMN1; SMN2MAPTHTTEGFRNPC1 | |
| SCHEMBL25795053 | 0.76 | TP53 (0.31) | POLB | |
| SCHEMBL27195850 | 0.76 | SLC6A2 (0.45) | SMN1; SMN2TRPM8SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4009400 | 0.74 | NOTUM (0.41) | POLB | |
| SCHEMBL25793248 | 0.70 | CA2 (0.41) | SMN1; SMN2MAPTALDH1A1HTTNPC1 | |
| SCHEMBL20320549 | 0.69 | SLC6A2 (0.40) | SMN1; SMN2TRPM8SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4021904-B1 | ALPHA-D-GALACTOPYRANOSIDE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-01-03 | — | — | EP | disclosed |
| WO-2021242505-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2021-12-02 | — | — | WO | disclosed |