Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25023188 | 0.90 | SMN1; SMN2 (0.67) | SMN1; SMN2SIRT2SIRT1HTTALDH1A1 | |
| SCHEMBL25022751 | 0.89 | SIRT1 (0.59) | SMN1; SMN2SIRT2SIRT1HTTALDH1A1 | |
| SCHEMBL24073265 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2SIRT2SIRT1HTTALDH1A1 | |
| SCHEMBL25023220 | 0.85 | CYP3A4 (0.53) | SMN1; SMN2SIRT2SIRT1ALDH1A1LMNA | |
| SCHEMBL25023221 | 0.84 | SIRT1 (0.55) | SMN1; SMN2SIRT2SIRT1HTTALDH1A1 | |
| SCHEMBL25022935 | 0.82 | SIRT2 (0.49) | SMN1; SMN2SIRT2SIRT1HTTALDH1A1 | |
| SCHEMBL12415397 | 0.80 | SMN1; SMN2 (0.79) | SMN1; SMN2HTTALDH1A1LMNAKMT2A | |
| SCHEMBL27188801 | 0.80 | MAPK1 (0.59) | SMN1; SMN2ALDH1A1LMNANPC1GLA | |
| SCHEMBL1710890 | 0.80 | ALDH1A1 (0.65) | SMN1; SMN2HTTALDH1A1LMNAKMT2A | |
| SCHEMBL10255967 | 0.79 | ALDH1A1 (0.67) | SMN1; SMN2HTTALDH1A1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021242923-A1 | TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | AXIAL THERAPEUTICS, INC. (US) | 2021-12-02 | — | — | WO | disclosed |