Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 11/20 | 0.45 |
| ▸ | LIMK2 | P53671 | 11/20 | 0.45 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30595945 | 0.89 | TNK2 (0.47) | TNK2LIMK1LIMK2CDK9JAK1 | |
| SCHEMBL30595948 | 0.89 | TNK2 (0.47) | TNK2LIMK1LIMK2CDK9JAK1 | |
| SCHEMBL30595928 | 0.88 | TNK2 (0.47) | TNK2LIMK1LIMK2CDK9JAK1 | |
| SCHEMBL30595929 | 0.86 | TNK2 (0.45) | TNK2LIMK1LIMK2CDK9JAK1 | |
| SCHEMBL30595936 | 0.85 | TNK2 (0.44) | TNK2LIMK1LIMK2CDK9PDK4 | |
| SCHEMBL30595965 | 0.85 | CDK9 (0.47) | TNK2LIMK1LIMK2CDK9PDK4 | |
| SCHEMBL30595923 | 0.80 | LIMK1 (0.64) | TNK2LIMK1LIMK2CDK9PDK4 | |
| SCHEMBL30595921 | 0.76 | LIMK1 (0.51) | TNK2LIMK1LIMK2 | |
| SCHEMBL4008367 | 0.76 | LIMK1 (0.51) | TNK2LIMK1LIMK2 | |
| SCHEMBL30595935 | 0.76 | LIMK1 (0.59) | TNK2LIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157844-B1 | 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER | CENTRE NAT RECH SCIENT (FR) | 2024-07-10 | — | — | EP | disclosed |
| WO-2021239727-A1 | 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2021-12-02 | — | — | WO | disclosed |