Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24075154 | 0.91 | P2RX7 (0.30) | — | |
| SCHEMBL25877384 | 0.84 | — | — | |
| SCHEMBL25877390 | 0.81 | PDE10A (0.34) | — | |
| SCHEMBL24073863 | 0.81 | MEN1 (0.36) | — | |
| SCHEMBL24073836 | 0.78 | PTAFR (0.35) | — | |
| SCHEMBL26020398 | 0.77 | — | — | |
| SCHEMBL24074975 | 0.77 | PTAFR (0.35) | — | |
| SCHEMBL25934635 | 0.75 | — | — | |
| SCHEMBL25934604 | 0.75 | PLA2G2A (0.31) | — | |
| SCHEMBL24123722 | 0.72 | CYP4F2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022129333-A1 | BRANCHED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022008674-A1 | MACROCYCLIC ETHER CONTAINING INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | JANSSEN PHARMACEUTICA NV (BE) | 2022-01-13 | — | — | WO | disclosed |
| WO-2021239862-A1 | MACROCYCLIC 7-PYRAZOL-5-YL-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | JANSSEN PHARMACEUTICA NV (BE) | 2021-12-02 | — | — | WO | disclosed |