Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNF4 | P78317 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | MITF | O75030 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23748680 | 0.86 | RNF4 (0.71) | RNF4ALDH1A1HTTMITFPOLB | |
| SCHEMBL31703396 | 0.83 | RNF4 (0.73) | RNF4ALDH1A1HTTMITFPOLB | |
| SCHEMBL3382618 | 0.82 | RNF4 (1.00) | RNF4ALDH1A1HTTMITFPOLB | |
| SCHEMBL11806908 | 0.82 | RNF4 (0.86) | RNF4ALDH1A1HTTMITFPOLB | |
| SCHEMBL21392901 | 0.82 | RNF4 (0.71) | RNF4ALDH1A1HTTMITFPOLB | |
| SCHEMBL2636652 | 0.79 | NPSR1 (0.61) | ALDH1A1HTTMITFPOLBMAPK1 | |
| SCHEMBL23748593 | 0.79 | RNF4 (0.66) | RNF4ALDH1A1HTTMITFPOLB | |
| SCHEMBL23748677 | 0.79 | RNF4 (0.75) | RNF4ALDH1A1HTTMITFPOLB | |
| SCHEMBL31536277 | 0.79 | RNF4 (0.75) | RNF4ALDH1A1HTTMITFPOLB | |
| SCHEMBL21392968 | 0.76 | RNF4 (0.76) | RNF4ALDH1A1HTTMITFPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210369731-A1 | COVALENT TARGETING OF E3 LIGASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210369731-A1 | COVALENT TARGETING OF E3 LIGASES | RNF114, RNF4, RNF168 | RNF4 2/4885ALDH1A1 2969/4885HTT 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.