Sugi Predict

Sugi Predict / Compounds / SCHEMBL23748680

SCHEMBL23748680

SCHEMBL23748680

O=C(CCl)Nc1ccc(Oc2ccc(CO)cc2)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RNF4 P78317 1/20 0.71
▸ MEN1 O00255 4/20 0.55
▸ KMT2A Q03164 4/20 0.55
▸ ALDH1A1 P00352 8/20 0.54
▸ HTT P42858 4/20 0.54
▸ MITF O75030 3/20 0.54
▸ POLB P06746 1/20 0.54
▸ MAPK1 P28482 1/20 0.54
▸ NPC1 O15118 2/20 0.51
▸ RAB9A P51151 2/20 0.51
▸ XBP1 P17861 1/20 0.51
▸ NPSR1 Q6W5P4 1/20 0.51
▸ NOD2 Q9HC29 1/20 0.51
▸ SMN1; SMN2 Q16637 2/20 0.51
▸ LMNA P02545 2/20 0.51
▸ MAPT P10636 2/20 0.51
▸ CYP1A2 P05177 1/20 0.51
▸ GLA P06280 1/20 0.51
▸ CYP3A4 P08684 1/20 0.51
▸ CYP2C19 P33261 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11806908 0.90 RNF4 (0.86) RNF4MEN1KMT2AALDH1A1HTT
SCHEMBL2636162 0.90 NPC1 (0.61) RNF4MEN1KMT2AALDH1A1HTT
SCHEMBL24075754 0.86 RNF4 (0.69) RNF4ALDH1A1HTTMITFPOLB
SCHEMBL21392968 0.83 RNF4 (0.76) RNF4MEN1KMT2AALDH1A1HTT
SCHEMBL3382618 0.83 RNF4 (1.00) RNF4MEN1KMT2AALDH1A1HTT
SCHEMBL23748676 0.82 RNF4 (0.73) RNF4MEN1KMT2AALDH1A1HTT
SCHEMBL14702222 0.81 SMN1; SMN2 (0.54) RNF4MEN1KMT2AALDH1A1HTT
SCHEMBL9081388 0.78 NPC1 (0.76) RNF4MEN1KMT2AALDH1A1HTT
SCHEMBL25167513 0.78 RNF4 (0.68) RNF4MEN1KMT2AALDH1A1HTT
SCHEMBL23748639 0.78 RNF4 (0.68) RNF4KMT2AALDH1A1HTTMITF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113164495-B Covalent targeting of E3 ligases 加利福尼亚大学董事会 2025-04-22 — — CN disclosed
US-20250120982-A1 COVALENT TARGETING OF E3 LIGASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2025-04-17 — — US disclosed
US-12161648-B2 Covalent targeting of E3 ligases THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-12-10 — — US disclosed
US-20210369731-A1 COVALENT TARGETING OF E3 LIGASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2021-12-02 — — US disclosed
EP-3863642-A1 COVALENT TARGETING OF E3 LIGASES The Regents of the University of California (US) 2021-08-18 — — EP disclosed
CN-113164495-A Covalent targeting of E3 ligase 加利福尼亚大学董事会 2021-07-23 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12161648-B2 Covalent targeting of E3 ligases RNF114, RNF4, RNF168 RNF4 2/4885MEN1 2638/4885KMT2A 501/4885
US-20210369731-A1 COVALENT TARGETING OF E3 LIGASES RNF114, RNF4, RNF168 RNF4 2/4885MEN1 2638/4885KMT2A 501/4885
US-20250120982-A1 COVALENT TARGETING OF E3 LIGASES STUB1, XIAP, RBX1 RNF4 13/4885MEN1 4382/4885KMT2A 869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.