Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.57 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 3/20 | 0.39 |
| ▸ | RORA | P35398 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24077226 | 0.86 | NLRP3 (0.54) | NLRP3DHODHRORARORCRORB | |
| SCHEMBL24076327 | 0.86 | NLRP3 (0.64) | NLRP3GPR139AKR1B1 | |
| SCHEMBL30168567 | 0.86 | NLRP3 (0.64) | NLRP3GPR139AKR1B1 | |
| SCHEMBL24076302 | 0.84 | NLRP3 (0.62) | NLRP3GPR139AKR1B1MAPTLMNA | |
| SCHEMBL24076307 | 0.83 | NLRP3 (0.58) | NLRP3GPR139MEN1ALDH1A1POLB | |
| SCHEMBL26732911 | 0.82 | NLRP3 (0.63) | NLRP3GPR139AKR1B1MAPT | |
| SCHEMBL29426566 | 0.82 | NLRP3 (0.63) | NLRP3GPR139AKR1B1MAPT | |
| SCHEMBL24076964 | 0.82 | NLRP3 (0.68) | NLRP3GPR139AKR1B1MAPTSMN1; SMN2 | |
| SCHEMBL30636646 | 0.79 | NLRP3 (0.57) | NLRP3GPR139AKR1B1MAPTLMNA | |
| SCHEMBL24077080 | 0.79 | AKR1B1 (0.46) | NLRP3BRD9RORARORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021239885-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-12-02 | — | — | WO | disclosed |