Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 9/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30168567 | 0.91 | NLRP3 (0.64) | NLRP3ALOX15AKR1B1 | |
| SCHEMBL24076327 | 0.91 | NLRP3 (0.64) | NLRP3ALOX15AKR1B1 | |
| SCHEMBL24077152 | 0.89 | NLRP3 (0.56) | NLRP3ALOX15AKR1B1RAB9ATSHR | |
| SCHEMBL24077053 | 0.89 | NLRP3 (0.56) | NLRP3ALOX15AKR1B1RAB9ATSHR | |
| SCHEMBL24076927 | 0.87 | NLRP3 (0.50) | NLRP3POLB | |
| SCHEMBL24077049 | 0.87 | NLRP3 (0.52) | NLRP3ALOX15AKR1B1RAB9ATSHR | |
| SCHEMBL24077043 | 0.86 | NLRP3 (0.52) | NLRP3ALOX15AKR1B1RAB9ATSHR | |
| SCHEMBL24076943 | 0.83 | NLRP3 (0.49) | NLRP3ALOX15AKR1B1RAB9ATSHR | |
| SCHEMBL25747845 | 0.82 | NLRP3 (0.56) | NLRP3ALOX15AKR1B1 | |
| SCHEMBL24076302 | 0.81 | NLRP3 (0.62) | NLRP3AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230202989-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-29 | — | — | US | disclosed |
| US-20230202989-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-29 | — | — | US | disclosed |
| WO-2021239885-A1 | COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230202989-A1 | COMPOUNDS | NLRP3, NLRP1, IL1B | NLRP3 1/4885ALOX15 289/4885AKR1B1 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.