⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91420 | 0.76 | — | — | |
| SCHEMBL77889 | 0.76 | — | — | |
| SCHEMBL18391843 | 0.76 | — | — | |
| SCHEMBL3509445 | 0.76 | — | — | |
| SCHEMBL1235280 | 0.76 | — | — | |
| SCHEMBL936052 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL68621 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL17374691 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL307150 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL7302305 | 0.74 | GABRA5 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108503605-A | A kind of preparation method of acotiamide hydrochloride hydrate key intermediate | 南安市创培电子科技有限公司 | 2018-09-07 | — | — | CN | claimed |
| CN-108358867-A | A kind of synthetic method of acotiamide hydrochloride hydrate | 邳州易萨新型材料有限公司 | 2018-08-03 | — | — | CN | claimed |
| CN-108218809-A | A kind of synthetic method of medicine intermediate thiazolamine -4- Ethyl formates | 邳州易萨新型材料有限公司 | 2018-06-29 | — | — | CN | claimed |
| CN-106800539-A | A kind of acotiamide hydrochloride hydrate intermediate and its synthesis technique and application | 江苏吴中医药集团有限公司苏州制药厂 | 2017-06-06 | — | — | CN | claimed |
| CN-101967209-B | N-acetylethylenediamine chelate resin and preparation method thereof | NANJING UNIVERSITY OF TECHNOLOGY | 2012-11-07 | — | — | CN | claimed |
| CN-101967209-A | N-acetylethylenediamine chelate resin and preparation method thereof | NANJING UNIVERSITY OF TECHNOLOGY | 2011-02-09 | — | — | CN | claimed |
| CN-109776447-B | Industrial production method of acotiamide hydrochloride | 常州市阳光药业有限公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-109776447-A | Acotiamide hydrochloride hydrate industrialized preparing process | 常州市阳光药业有限公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-108503605-A | A kind of preparation method of acotiamide hydrochloride hydrate key intermediate | 南安市创培电子科技有限公司 | 2018-09-07 | — | — | CN | disclosed |
| CN-108473508-A | Heterocyclic substituted bicyclic azole insecticides | FMC公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-105612162-B | Thiazolopyrimidinones as modulators of NMDA receptor activity | 豪夫迈·罗氏有限公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-108383858-A | Treat the derivative of the imidazo thiadiazoles and Imidazopyrazines of platelet aggregation | 百时美施贵宝公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-108358867-A | A kind of synthetic method of acotiamide hydrochloride hydrate | 邳州易萨新型材料有限公司 | 2018-08-03 | — | — | CN | disclosed |
| WO-1996000224-A1 | 4-S- AND N-SUBSTITUTED 6-ALKYLPYRIDINES FOR CONTROLLING HELICOBACTER BACTERIA | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-01-04 | — | — | WO | disclosed |
| WO-1995034553-A1 | THIOPYRIDINES FOR USE IN THE CONTROL OF HELICOBACTER BACTERIA | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1995-12-21 | — | — | WO | disclosed |
| EP-0683776-A1 | SUBSTITUTED HETEROARYLALKYLTHIOPYRIDINES FOR CONTROLLING HELICOBACTER BACTERIA | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994019346-A1 | SUBSTITUTED HETEROARYLALKYLTHIOPYRIDINES FOR CONTROLLING HELICOBACTER BACTERIA | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-09-01 | — | — | WO | disclosed |
| EP-0035228-B1 | TETRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND ANTI-ULCER COMPOSITION CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-01-02 | — | — | EP | disclosed |
| US-4372953-A | Tetrazole derivatives, and anti-ulcer composition containing the same | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1983-02-08 | — | — | US | disclosed |
| EP-0035228-A1 | Tetrazole derivatives, process for the preparation thereof, and anti-ulcer composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1981-09-09 | — | — | EP | disclosed |