SCHEMBL24084232

SCHEMBL24084232

N#Cc1cccc(F)c1-c1cccc(Cl)c1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCAT1 P54687 1/20 0.41
PDK2 Q15119 1/20 0.38
GRIA1 P42261 1/20 0.38
CACNG8 Q8WXS5 1/20 0.38
ALDH1A1 P00352 2/20 0.37
HTT P42858 1/20 0.37
AR P10275 1/20 0.37
CYP11B2 P19099 2/20 0.36
DYRK1A Q13627 1/20 0.36
GABRA1 P14867 3/20 0.35
GABRG2 P18507 3/20 0.35
GABRB3 P28472 3/20 0.35
GABRA5 P31644 3/20 0.35
GABRA3 P34903 3/20 0.35
CNR2 P34972 2/20 0.34
CNR1 P21554 1/20 0.34
L3MBTL1 Q9Y468 2/20 0.33
SMARCA2 P51531 1/20 0.33
SMARCA4 P51532 1/20 0.33
PBRM1 Q86U86 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24084229 0.83 PDK2 (0.43) BCAT1PDK2GRIA1CACNG8ALDH1A1
SCHEMBL24084247 0.82 ADORA2A (0.43) BCAT1ARCYP11B2DYRK1ACNR2
SCHEMBL1605889 0.80 PDK2 (0.46) BCAT1PDK2ALDH1A1CYP11B2GABRA1
SCHEMBL2651882 0.80 BCAT1 (0.41) BCAT1PDK2CYP11B2DYRK1AGABRA1
SCHEMBL2651366 0.78 ESR2 (0.46) BCAT1PDK2CYP11B2GABRG2GABRB3
SCHEMBL29741728 0.78 DYRK1A (0.44) BCAT1GRIA1CACNG8ALDH1A1AR
SCHEMBL1813129 0.78 DYRK1A (0.44) BCAT1GRIA1CACNG8ALDH1A1AR
SCHEMBL9069188 0.75 ESR2 (0.43) BCAT1PDK2ARCYP11B2GABRA1
SCHEMBL24084268 0.74 AR (0.51) ARCYP11B2CYP11B1
SCHEMBL24084180 0.74 AR (0.48) ALDH1A1ARCYP11B2CNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3700997-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2021-12-08 EP disclosed