Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6352725 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTGAANPSR1 | |
| SCHEMBL23130243 | 0.79 | NPC1 (0.42) | ALDH1A1KDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL15987826 | 0.79 | MAPT (0.39) | ALDH1A1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL31466216 | 0.71 | L3MBTL1 (0.43) | ALDH1A1KDM4EMAPTGAAL3MBTL1 | |
| SCHEMBL11107461 | 0.70 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTGAANPSR1 | |
| SCHEMBL6158008 | 0.69 | KDM4E (0.34) | ALDH1A1KDM4EMAPTGAANPSR1 | |
| SCHEMBL25900771 | 0.68 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTGAANPSR1 | |
| SCHEMBL16000553 | 0.68 | HDAC8 (0.46) | ALDH1A1KDM4EMAPTGAANPSR1 | |
| SCHEMBL31233793 | 0.64 | KDM4E (0.46) | ALDH1A1KDM4EMAPTGAANPSR1 | |
| SCHEMBL2019795 | 0.64 | APP (0.53) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130084245-A1 | PET MONITORING OF A-BETA-DIRECTED IMMUNOTHERAPY | WYETH LLC (US) | 2013-04-04 | — | — | US | disclosed |
| US-20130084245-A1 | PET MONITORING OF A-BETA-DIRECTED IMMUNOTHERAPY | WYETH LLC (US) | 2013-04-04 | — | — | US | disclosed |
| US-20130084245-A1 | PET MONITORING OF A-BETA-DIRECTED IMMUNOTHERAPY | WYETH LLC (US) | 2013-04-04 | — | — | US | disclosed |
| EP-2538982-A1 | PET MONITORING OF AB-DIRECTED IMMUNOTHERAPY | Janssen Alzheimer Immunotherapy (IE) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011106732-A1 | PET MONITORING OF AB-DIRECTED IMMUNOTHERAPY | WYETH LLC (US) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011106732-A1 | PET MONITORING OF AB-DIRECTED IMMUNOTHERAPY | WYETH LLC (US) | 2011-09-01 | — | — | WO | disclosed |
| US-20050271584-A1 | Biphenyls and fluorenes as imaging agents in alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2005-12-08 | — | — | US | disclosed |
| EP-1553985-A2 | BIPHENYLS AND FLUORENES AS IMAGING AGENTS IN ALZHEIMER'S DISEASE | The Trustees of The University of Pennsylvania (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004032975-A2 | BIPHENYLS AND FLUORENES AS IMAGING AGENTS IN ALZHEIMER'S DISEASE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2004-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130084245-A1 | PET MONITORING OF A-BETA-DIRECTED IMMUNOTHERAPY | APBA1, APP, BACE1 | ALDH1A1 2529/4885KDM4E 4381/4885MAPT 8/4885 |
| US-20050271584-A1 | Biphenyls and fluorenes as imaging agents in alzheimer's disease | APP, BACE2, BACE1 | ALDH1A1 1533/4885KDM4E 3436/4885MAPT 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.