Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | PIK3R5 | Q8WYR1 | 4/20 | 0.39 |
| ▸ | PIK3R3 | Q92569 | 4/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21855567 | 0.85 | PIK3CD (0.38) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21855636 | 0.85 | HPGD (0.38) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21995891 | 0.84 | ALOX15 (0.41) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL24088495 | 0.82 | PLAT (0.38) | ALDH1A1LMNANPC1 | |
| SCHEMBL21752599 | 0.79 | STAT3 (0.41) | ALDH1A1LMNANPC1 | |
| SCHEMBL31011271 | 0.79 | STAT3 (0.41) | ALDH1A1LMNANPC1 | |
| SCHEMBL21855731 | 0.77 | PIK3CD (0.39) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21855518 | 0.74 | EPHX1 (0.43) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL21752501 | 0.73 | KMT2A (0.40) | TP53ALDH1A1NPC1 | |
| SCHEMBL21752707 | 0.73 | ALDH1A1 (0.36) | ALDH1A1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210380572-A1 | NOVEL ARYLALKYL PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210380572-A1 | NOVEL ARYLALKYL PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | IDO1, IDO2, AADAC | PIK3CD 2113/4885PIK3R2 2802/4885PIK3CA 2650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.