Maleic Acid

Maleic Acid

SCHEMBL2408876

C/C(=C/C(=O)O)C(=O)O.O=C(O)/C=C\C(=O)O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol

The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.50
TP53 P04637 1/20 0.50
EGLN1 Q9GZT9 1/20 0.50
EGLN3 Q9H6Z9 1/20 0.50
ALDH1A1 P00352 3/20 0.41
TDP1 Q9NUW8 3/20 0.41
ALOX15 P16050 1/20 0.41
RECQL P46063 1/20 0.41
HSD17B10 Q99714 1/20 0.41
HTT P42858 2/20 0.41
HCAR2 Q8TDS4 3/20 0.40
PTGS1 P23219 1/20 0.39
KMT2A Q03164 1/20 0.36
GAA P10253 1/20 0.36
POLB P06746 2/20 0.35
MAPT P10636 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
KDM4E B2RXH2 2/20 0.35
PKM P14618 1/20 0.35
AKR1C3 P42330 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fumaric Acid SCHEMBL2408880 1.00 TSHR (0.50) TSHRTP53EGLN1EGLN3ALDH1A1
Maleic Acid SCHEMBL30781489 1.00 TSHR (0.50) TSHRTP53EGLN1EGLN3ALDH1A1
Fumaric Acid SCHEMBL30063112 0.95 TSHR (0.45) TSHRTP53EGLN1EGLN3ALDH1A1
SCHEMBL623108 0.91 HTT (0.45) TSHRALDH1A1TDP1HTTPTGS1
SCHEMBL5893 0.91
SCHEMBL27531633 0.91 HTT (0.45) TSHRALDH1A1TDP1HTTPTGS1
SCHEMBL28517 0.91
SCHEMBL623803 0.91 HTT (0.45) TSHRALDH1A1TDP1HTTPTGS1
SCHEMBL5894 0.91
SCHEMBL6040109 0.91 HTT (0.45) TSHRALDH1A1TDP1HTTPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4879412-A SOLVENT EXTRACTION, ION EXCHANGING MITSUI TOATSU CHEMICALS, INC. (JP) 1989-11-07 US claimed
CN-86102590-B Method for purifying methacrylic acid 三井东压化学有限公司 1988-08-03 CN claimed
EP-2547528-B1 LIQUID DROPLET EJECTING METHOD, LIQUID DROPLET EJECTION APPARATUS, INKJET RECORDING APPARATUS, PRODUCTION METHOD OF FINE PARTICLES, FINE PARTICLE PRODUCTION APPARATUS, AND TONER RICOH CO LTD (JP) 2024-05-08 EP disclosed
CN-110618583-B Colored resin composition, color filter, and image display device 三菱化学株式会社 2024-02-23 CN disclosed
CN-107429078-B Colored resin composition, color filter, and image display device 三菱化学株式会社 2019-10-15 CN disclosed
CN-107429078-A Colored resin composition, color filter, and image display device 三菱化学株式会社 2017-12-01 CN disclosed
US-9682556-B2 Liquid droplet ejecting method, liquid droplet ejection apparatus, inkjet recording apparatus, production method of fine particles, fine particle production apparatus, and toner RICOH COMPANY, LTD. (JP) 2017-06-20 US disclosed
US-20140292947-A1 LIQUID DROPLET EJECTING METHOD, LIQUID DROPLET EJECTION APPARATUS, INKJET RECORDING APPARATUS, PRODUCTION METHOD OF FINE PARTICLES, FINE PARTICLE PRODUCTION APPARATUS, AND TONER NORIKANE YOSHIHIRO (JP) 2014-10-02 US disclosed
US-8797373-B2 Liquid droplet ejecting method, liquid droplet ejection apparatus, inkjet recording apparatus, production method of fine particles, fine particle production apparatus, and toner RICOH COMPANY, LTD. (JP) 2014-08-05 US disclosed
US-8652744-B2 Method for manufacturing toner and toner RICOH COMPANY, LTD. (JP) 2014-02-18 US disclosed
EP-2547528-A1 LIQUID DROPLET EJECTING METHOD, LIQUID DROPLET EJECTION APPARATUS, INKJET RECORDING APPARATUS, PRODUCTION METHOD OF FINE PARTICLES, FINE PARTICLE PRODUCTION APPARATUS, AND TONER Ricoh Company, Ltd. (JP) 2013-01-23 EP disclosed
US-6100342-A SOLVENT POLYMERIZING CARBOXY-FUNCTIONAL ACRYLATE COPOLYMERS, SEPARATING AND REACTING THE COPOLYMERS WITH A MOLAR EXCESS OF EPIHALOALKANE, REACTING THE COPOLYMERS WITH SODIUM HYDROXIDE EMS-INVENTA AG (CH) 2000-08-08 US disclosed
EP-0698061-A4 LAMINATING RESINS HAVING LOW ORGANIC EMISSIONS ARISTECH CHEMICAL CORP (US) 1998-03-25 EP disclosed
US-5567767-A UNSATURATED POLYESTER, DI(METH) ACRYLATE OF ALKYLOXYLATED BISPHENOL A, AND VINYL TOLUENE ARISTECH CHEMICAL CORPORATION (US) 1996-10-22 US disclosed
EP-0698061-A1 LAMINATING RESINS HAVING LOW ORGANIC EMISSIONS Aristech Chemical Corporation (US) 1996-02-28 EP disclosed
WO-1995023828-A1 LAMINATING RESINS HAVING LOW ORGANIC EMISSIONS ARISTECH CHEMICAL CORPORATION (US) 1995-09-08 WO disclosed
EP-0359796-A1 THERMOSETTING COMPOSITION FROM MALEIMIDE, OLEFINIC MONOMER AND UNSATURATED POLYESTER. ARISTECH CHEMICAL CORP (US) 1990-03-28 EP disclosed
WO-1989008670-A1 THERMOSETTING COMPOSITION FROM MALEIMIDE, OLEFINIC MONOMER AND UNSATURATED POLYESTER ARISTECH CHEMICAL CORPORATION (US) 1989-09-21 WO disclosed
EP-0167304-A1 Addition polyimide composition The British Petroleum Company p.l.c. (GB) 1986-01-08 EP disclosed
US-4499248-A Poly-diisopropenyl benzene synthesis THE GOODYEAR TIRE & RUBBER COMPANY (US) 1985-02-12 US disclosed