Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2407101 | 0.99 | HTR2C (0.36) | HTR2CSLC6A4HTR2ACOMTALDH1A1 | |
| Hydrochloric Acid SCHEMBL4422134 | 0.94 | HTR2C (0.33) | HTR2CSLC6A4HTR2ANAMPTOPRM1 | |
| Hydrochloric Acid SCHEMBL4420974 | 0.93 | HTR2C (0.33) | HTR2CSLC6A4HTR2AOPRM1OPRK1 | |
| SCHEMBL2410597 | 0.92 | HTT (0.34) | HTR2CSLC6A4HTR2AATMGPR119 | |
| SCHEMBL5002540 | 0.88 | PLAU (0.34) | COMTALDH1A1ATMSMN1; SMN2PLAU | |
| SCHEMBL2409312 | 0.87 | COMT (0.33) | COMTALDH1A1ATMSMN1; SMN2PLAU | |
| SCHEMBL2409727 | 0.86 | HTR2C (0.41) | HTR2CSLC6A4HTR2ACOMTSSTR4 | |
| SCHEMBL1834426 | 0.83 | HTR2C (0.33) | HTR2CSLC6A4HTR2AGPR119SSTR4 | |
| SCHEMBL2414689 | 0.83 | RIPK1 (0.35) | HTR2CSLC6A4HTR2ASSTR4 | |
| SCHEMBL2410515 | 0.83 | HTR2C (0.33) | HTR2CSLC6A4HTR2ASSTR4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |