Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.42 |
| ▸ | CDK1 | P06493 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21473730 | 0.85 | CCNB2 (0.43) | LMNATP53CCNB2CDK1CCNB1 | |
| SCHEMBL22000964 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNANPC1TP53RAB9A | |
| SCHEMBL22521467 | 0.80 | LMNA (0.47) | SMN1; SMN2LMNANPC1TP53RAB9A | |
| SCHEMBL13057326 | 0.78 | IRAK4 (0.55) | LMNANPC1TP53RAB9AKDM4E | |
| SCHEMBL6363779 | 0.76 | CCNB2 (0.37) | SRCCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL12946398 | 0.75 | ADORA2A (0.40) | CCNB2CDK1CCNB1CCNB3CDK2 | |
| SCHEMBL22521472 | 0.74 | CCNB2 (0.40) | SRCCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL30544134 | 0.74 | ADORA2A (0.54) | SRC | |
| SCHEMBL13261105 | 0.74 | ADORA2A (0.39) | SRCCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL10255769 | 0.74 | ADORA2A (0.39) | SRCCCNB2CDK1CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11198699-B2 | Compounds targeting PRMT5 | ALIGOS THERAPEUTICS, INC. (US) | 2021-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11198699-B2 | Compounds targeting PRMT5 | PRMT5, PRMT1, PRMT6 | SMN1; SMN2 496/4885LMNA 2624/4885NPC1 1258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.