Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19567880 | 1.00 | JAK2 (0.44) | JAK2JAK1BCHEACHEBACE1 | |
| SCHEMBL19567380 | 1.00 | JAK2 (0.44) | JAK2JAK1BCHEACHEBACE1 | |
| SCHEMBL19567372 | 0.86 | LOXL2 (0.45) | JAK2JAK1OPRM1OPRL1HRH3 | |
| SCHEMBL19567883 | 0.86 | POLB (0.54) | JAK2JAK1BCHEACHEBACE1 | |
| SCHEMBL19567370 | 0.86 | LOXL2 (0.45) | JAK2JAK1OPRM1OPRL1HRH3 | |
| SCHEMBL19567413 | 0.86 | POLB (0.54) | JAK2JAK1BCHEACHEBACE1 | |
| SCHEMBL19567649 | 0.86 | POLB (0.54) | JAK2JAK1BCHEACHEBACE1 | |
| SCHEMBL19567386 | 0.86 | OPRM1 (0.55) | JAK2JAK1BCHEACHEBACE1 | |
| SCHEMBL19567419 | 0.86 | OPRM1 (0.55) | JAK2JAK1BCHEACHEBACE1 | |
| SCHEMBL23514508 | 0.85 | CARM1 (0.50) | JAK2JAK1ACHEBACE1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452464-B1 | PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF | HOFFMANN LA ROCHE (CH) | 2021-12-15 | — | — | EP | disclosed |