Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 6/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17962768 | 0.85 | RET (0.53) | RETMAPK1KDM4ECYP1A2TP53 | |
| SCHEMBL24096881 | 0.80 | CYP1A2 (0.68) | RETMAPK1KDM4ECYP1A2TP53 | |
| SCHEMBL10261498 | 0.79 | PIK3CD (0.53) | RETMAPK1KDM4ECYP1A2TP53 | |
| SCHEMBL10261070 | 0.78 | SRC (0.52) | RETMAPK1KDM4ECYP1A2TP53 | |
| SCHEMBL24072107 | 0.75 | RET (0.54) | RETMAPK1KDM4ECYP1A2TP53 | |
| SCHEMBL24096616 | 0.74 | PRKD3 (0.58) | RETMAPK1KDM4ECYP1A2TP53 | |
| SCHEMBL29998849 | 0.74 | PRKD3 (0.58) | RETMAPK1KDM4ECYP1A2TP53 | |
| SCHEMBL21028946 | 0.74 | PIK3CD (0.55) | MAPK1KDM4ECYP1A2TP53CYP3A4 | |
| SCHEMBL22215343 | 0.74 | PIK3CD (0.55) | RETMAPK1KDM4ECYP1A2TP53 | |
| SCHEMBL26148251 | 0.74 | MAPK1 (0.42) | RETMAPK1KDM4ECYP1A2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252488-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |