Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.55 |
| ▸ | PRKDC | P78527 | 4/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | HCK | P08631 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26148251 | 0.84 | MAPK1 (0.42) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL24096485 | 0.83 | PIK3CG (0.54) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1923309 | 0.83 | PIK3CD (0.40) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30321059 | 0.83 | PIK3CG (0.54) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16864520 | 0.82 | PIK3CD (0.54) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL10261498 | 0.80 | PIK3CD (0.53) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL10261070 | 0.76 | SRC (0.52) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13019688 | 0.76 | PIK3CD (0.68) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL22215343 | 0.75 | PIK3CD (0.55) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL24096856 | 0.74 | RET (0.55) | SRCABL1EGFRKDRMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613743-A1 | PROCESSES FOR THE PREPARATION OF 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE DERIVATIVES | Intellikine, LLC (US) | 2020-02-26 | — | — | EP | disclosed |
| EP-2240452-B1 | 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE DERIVATIVES AS PI3 KINASE MODULATORS, THEIR COMPOSITIONS AND USES | INTELLIKINE LLC (US) | 2019-05-29 | — | — | EP | disclosed |